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Image Search Results
Journal: Redox biology
Article Title: Selective nitration of Hsp90 acts as a metabolic switch promoting tumor cell proliferation.
doi: 10.1016/j.redox.2024.103249
Figure Lengend Snippet: Fig. 5. Nitrated Hsp90 proliferative activity is mediated by activation of P2X7R. (A) Schwannoma (MN-Schwann cells), and (B) normal Schwann cell growth was assessed in the presence and absence of the P2X7R inhibitor KN-62 (10 μM). (C–D) Recombinant proteins were intracellularly delivered to schwannoma and normal Schwann cells and the cells incubated for 24 and 48 h in the presence and absence of the P2X7R inhibitor KN62 (10 μM). The ECAR and glycolytic parameters of (E–G) schwannoma cells, and (H–J) normal Schwann cells were measured 24 h after delivery. Data is shown using Tukey’s representation with the median indicated in the box plot and outliers indicated with dots (n = 3–8 with 8 replicates). *p < 0.05 versus Hsp90 by one-way ANOVA with Dunnett’s multiple com parisons post hoc test.
Article Snippet: The
Techniques: Activity Assay, Activation Assay, Recombinant, Incubation